Pharmaco-EEG studies are economically useful in clinically classifying new agents, dosage ranges and durations of effects, and separating active from inactive substances (if an agent passes the blood-brain barrier).
It helps answer questions like:
Does it pass the blood-brain barrier?
- How does it act?
- Is it sedating or stimulating?
- Where does it act?
- When does it act? (Pharmacokinetics, PK/PD modeling)
- At which dose does it act? (Pharmacodynamics)
In addition, EEG plays a critical role in the successful evaluation of a compound during drug development, particularly in the evaluation of seizure potential.
The advantages of EEG compared to other objective methods are:
- Minimally disturbing
- Highest available time and frequency resolution
- Sensitive to pharmacological effects on CNS with regard to pharmacokinetics and pharmacodynamics