Pharmaco-EEG

Pharmaco-EEG studies are economically useful in clinically classifying new agents, dosage ranges and durations of effects, and separating active from inactive substances (if an agent passes the blood-brain barrier).

It helps to answer questions like:

Is an investigational product active in the brain? Does it pass the blood-brain barrier?

  • How does it act?
  • Is it sedating or stimulating?
  • Where does it act?
  • When does it act? (Pharmacokinetics)
  • At which dose does it act? (Pharmacodynamics)

In addition, EEG plays a critical role in the successful evaluation of a compound during drug development, particularly in the evaluation of seizure potential.

The advantages of EEG compared to other objective methods are:

  • Non-invasive
  • Minimally disturbing
  • Highest available time and frequency resolution
  • Sensitive to pharmacological effects on CNS with regard to pharmacokinetics and pharmacodynamics