The Siesta Group

From Biosignal to Biomarker:We set the Benchmark

We empower pharma and biotechnology companies to unlock the full potential of information-rich EEG, polysomnography and actigraphy data. If there is a signal, we will find it.

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Our biomarker portfolio

Explore our portfolio by:
Sleep Disorders

For many major sleep disorders, such as Primary Insomnia or Narcolepsy, the supervised in-lab polysomnography (PSG) and derived endpoints like Wake-after-sleep-onset or Sleep Efficiency are the gold standard in drug trials. In addition, daytime measurements like the Multiple Sleep Latency Test are standard EEG-based measurements for vigilance or somnolence. But there are many more biomarkers that can be extracted from PSG, including the micro-structure of sleep (e.g. sleep spindles, REM density, etc.) or quantitative EEG during stable sleep stages.

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Sleep Apnea

The Apnea Hypopnea Index (AHI) derived from in-lab polysomnography (PSG) is the most well-known biomarker for Obstructive Sleep Apnea (OSA). But there are alternatives, such as the Hypoxic Burden Index, shown to correlate better to many outcome measures than the AHI. Lately, it has also been used in respiratory phenotyping.

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Neurodegenerative Diseases

Event-related Potentials (ERP), such as the well-known P300 in an acoustic oddball paradigm has been proven to be a major biomarker detecting and predicting cognitive decline in both Alzheimer’s and Parkinson’s disease. But also, quantitative EEG variables provide important information about the effects of the diseases. More recently, sleep-related biomarkers such as sleep spindle densities have been shown to be rather characteristic for changes in Alzheimer’s disease.

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Mood Disorders

Quantitative EEG is known to reveal important changes in the brain due to Major Depression Disorder (MDD), such as increases in the Delta bands. But also measuring sleep in MDD provides valuable endpoints for related drug trials. For instance, the relationship between latency to and amount of REM sleep to the extent of the disorder can guide early phase trials.

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Schizophrenia

EEG Biomarkers for Schizophrenia

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Autism

EEG Biomarkers for Autism

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Anxiety Disorders

EEG Biomarkers for Anxiety Disorders

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What makes us unique

Unwavering scientific DNAExceptional Team Proprietary Research
Scientific Leadership

Scientific Leadership

We were the first to develop a reliable computer-assisted sleep scoring tool and pride ourselves on continuing to set the gold standard for capturing, analyzing, and interpreting bio-signals.

Exceptional Team

Exceptional Team

Our team of scientists, technologists, and project managers brings their collective expertise to bear at every step of the process.

Software Innovations

Software Innovations

With our proprietary research and innovative solutions, we're breaking new ground and discovering new applications for our expertise every day.

Large Research Network

Large Research Network

We collaborate with a large international academic research network contributing to over 100 publications.

Globally Recognized

Globally Recognized

Partnering with sites spanning the globe, we acquired special attention appreciating cultural nuances and practices.

Experience

Experience

We have acquired 20+ years of experience in collecting and analyzing EEG biomarkers.

since 2002

Trusted by 30+ leading sponsors and CROs

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AI-powered Analysis

based on proprietary research and validation studies
including sleep staging, biomarker identification and patient classification such as

(1) next generation sleep staging equipped to process data from a variety of different recording technologies (from heart rate and respiratory signals to reduced and standard PSG)

(2) disease and compound specific biomarker identification through transparent AI-based classification techniques

Contact us for our AI services
AI-powered Analysis
Advanced Data Visualization

Advanced Data Visualization

optimized for high-dimensional data
including EEG topography & 3D source localisation

Data visualization is at the heart of translating scientific observations into clinical innovations. Therefore, The Siesta Group has always been pioneering the scientific validation and technical implementation of novel visualization tools for CNS clinical trials, such as LORETA (EEG-based source localization technique).

Contact us for data visualization possibilities

We Meet and Exceed Certification
& Compliance Standards

CH-GCP compliant
CH-GCP compliant
ICH GCP
GDPR compliant
GDPR compliant
Certified data protection officier
21CFR P11 compliant
21CFR P11 compliant
TSG has led consortium defining EDF
AASM certified
AASM certified
TSG was the only European contribution to AASM committee
IPEG conform
IPEG conform
TSG co-authored IPEG guidelines
45+ Audits
45+ Audits
including large Pharma, without any major findings

Python EDFio TSG's EDF library

simple and efficient reading/writing of EDF/EDF+ files
built on numpy
open source, commercially re-usable

European Data Format (EDF) and especially acknowledging its growing acceptance as quasi-standard file format in CNS clinical trials, we recognize the importance of our continuing contribution to the field.

Therefore, we decided to open source an actively maintained state-of-the-art python EDF reader/writer library (pyedfio) that fulfills the same rigorous quality standards that we apply to data handling in all CNS clinical trials we are involved in.

Explore on GitHub
Python EDFio
Python EDFio

Hypoxic Burden Platform

powered by The Siesta Calculator
open-access, actively maintained
with an intuitive user interface

Developed in collaboration with Harvard-Professor Dr. Ali Azerbazin the platform calculates the Hypoxic Burden Index (HBI), an integrated measure of both, rate and severity of apnea events. Therefore, HBI adds distinct analytical value to OSA studies in parallel to the standard AHI-endpoint.

Visit the HB platform
Our Strengths

Our Strengths

Our state of-the art, end to end biomarker platform helps researchers uncover visible, navigable and explainable biomarkers that may otherwise have gone unidentified, giving them unparalleled insights into a drugs effects across a wide range of psychiatric and neurological conditions.

Maximum Quality

Maximum quality through end to end solutions combining dedicated training, quality controlled data acquisition, benchmark central scoring, and state of-the art AI powered biomarker analysis.

End to end solutions

Experienced experts partner with you to ensure the highest quality support from study design and set up to data acquisition and analysis.

FDA-cleared Central Scoring

Our cutting edge technology, including Somnolyzer 24x7 continues to set the benchmark for the capture, analysis, and interpretation of bio signals.

Insights and Interpretation

Illuminating clinical insights and clear interpretation of drug effects through advanced data visualization techniques such as source localisation and spatio temporal clustering.

Device Agnostic

Not tied to a single product, we consult the most fit-for purpose solution. Our benchmark central scoring can be applied to any recording device, freeing you from relying on pre packed and rigid algorithms.

Transparent AI

We understand the crucial importance of testing AI derived biomarkers for their biological anchoring.

PPRS

PPRS

the strategic partnering organisation
from preclinical stages to NDA

Since 2016 The Siesta Group is a member of PPRS. A company that comprises of an expert team in the development of CNS drug-candidates and medical devices for CNS clinical trials, such as Somno-Art, an innovative home sleep measurement device

Learn more about PPRS

Somno-Art by PPRS

wearable medical device capturing detailed sleep data

Somno-Art utilizes the combination of heart rate variability and actimetry signals coupled with a state-of-the-art machine learning algorithm to extract detailed sleep biomarkers. Sleep architecture and derived endpoints show excellent correlation with results based on gold-standard manual scoring.

Learn more about Somno-Art
Somno-Art
HRV via plethys- mography
HRV via
plethysmography
3-axis actimetry
3-axis
actimetry
memory for 60 nights
memory for
96 nights
HRV via plethys- mography
40h
battery life
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Empire Clinical Research, Pomona/CA

Working with The Siesta Group has been a very positive experience, and we highly recommend the team. During our experience working with The Siesta Group on multiple studies, they have shown to be extremely knowledgeable and accessible. If our techs had any questions, they have been willing to schedule same day trainings and provide easy to follow instructions. This not only makes it easy to work with their team, but it also ensures the data is correct.

We have noticed there is a valuable difference working with The Siesta Group, over other PSG vendors in terms of quality. The difference in proper PSG data transmissions, set up, as well as their urgency which helps the study approval process go faster, and gets the site up and running in a shorter period of time.We highly recommend The Siesta Group and hope to work with them again in on this pivotal study.

Yogesh K. Paliwal, MD
November 9, 2020

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Our Device Agnostic Advantage

Integration Validation Testing

We select optimal technology for each study, empowering partners without being tied to specific products.

ActTrust
Arc Apollo
Arc Apollo
CentrePoint Insight Watch
Dreem_v2
Embrace Plus
GT3X BT
MotionWatch 8
Sleep Profiler
Device
Sleep Profiler
Sleep Profiler
Sleep Profiler
ActTrust
Arc Apollo
Arc Apollo
CentrePoint Insight Watch
Dreem_v2
Embrace Plus
GT3X BT
MotionWatch 8
Sleep Profiler
Device
Sleep Profiler
Sleep Profiler
Sleep Profiler
ActTrust
Arc Apollo
Arc Apollo
CentrePoint Insight Watch
Dreem_v2
Embrace Plus
GT3X BT
MotionWatch 8
Sleep Profiler
Device
Sleep Profiler
Sleep Profiler
Sleep Profiler
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